Fatsecret, commonly styled as fatsecret, is a mobile application, website and API that helps people achieve their weight loss goals and find accurate nutrition information. It also offers a weight loss clinic with coaching and medically supported programs. The platform powers global health apps. == History == Fatsecret was founded in 2006 in Melbourne, Australia by Lenny Moses and Rodney Moses. As of 2019, Lenny serves as the company's CEO. The company is known for its calorie counting and meal tracking app, and by April 2016, the company claimed to have 45 million users of its services. In August 2018, a premium version of its app was released. Since August 2009, the company has operated the Fatsecret Platform API, which allows access to its global food and nutrition database. Fatsecret reportedly had 900,000 downloads of its app in January 2020. In an analysis of several Health & Fitness app subcategories for the United States in January 2021, Fatsecret was reported to have the highest 30 day user retention rate of top Calorie Counter + Meal Planner for Weight Loss apps.
Non-photorealistic rendering
Non-photorealistic rendering (NPR) is an area of computer graphics that focuses on enabling a wide variety of expressive styles for digital art, in contrast to traditional computer graphics, which focuses on photorealism. NPR is inspired by other artistic modes such as painting, drawing, technical illustration, and animated cartoons. NPR has appeared in movies and video games in the form of cel-shaded animation (also known as "toon" shading) as well as in scientific visualization, architectural illustration and experimental animation. == History and criticism of the term == The term non-photorealistic rendering is believed to have been coined by the SIGGRAPH 1990 papers committee, who held a session entitled "Non Photo Realistic Rendering". The term has received some criticism: The term "photorealism" has different meanings for graphics researchers (see "photorealistic rendering") and artists. For artists—who are the target consumers of NPR techniques—it refers to a school of painting that focuses on reproducing the effect of a camera lens, with all the distortion and hyper-reflections that it creates. For graphics researchers, however, it refers to an image that is visually indistinguishable from reality. In fact, graphics researchers lump the kinds of visual distortions that are used by photorealist painters into "non-photorealism". Describing something by what it is not is problematic. Equivalent (made-up) comparisons might be "non-elephant biology" or "non-geometric mathematics". NPR researchers have stated that they expect the term will disappear eventually and be replaced by the now more general term "computer graphics", with "photorealistic graphics" being the term used to describe "traditional" computer graphics. Many techniques that are used to create 'non-photorealistic' images are not rendering techniques. They are modelling techniques, or post-processing techniques. While the latter are coming to be known as 'image-based rendering', sketch-based modelling techniques, cannot technically be included under this heading, which is very inconvenient for conference organisers. The first conference on non-photorealistic animation and rendering included a discussion of possible alternative names. Among those suggested were "expressive graphics", "artistic rendering", "non-realistic graphics", "art-based rendering", and "psychographics". All of these terms have been used in various research papers on the topic, but the "non-photorealistic" term seems to have nonetheless taken hold. The first technical meeting dedicated to NPR was the ACM-sponsored Symposium on Non-Photorealistic Rendering and Animation(NPAR) in 2000. NPAR is traditionally co-located with the Annecy Animated Film Festival, running on even numbered years. From 2007 onward, NPAR began to also run on odd-numbered years, co-located with ACM SIGGRAPH. == 3D == Three-dimensional NPR is the style that is most commonly seen in video games and movies. The output from this technique is almost always a 3D model that has been modified from the original input model to portray a new artistic style. In many cases, the geometry of the model is identical to the original geometry, and only the material applied to the surface is modified. With increased availability of programmable GPU's, shaders have allowed NPR effects to be applied to the rasterised image that is to be displayed to the screen. The majority of NPR techniques applied to 3D geometry are intended to make the scene appear two-dimensional. NPR techniques for 3D images include cel shading and Gooch shading. Many methods can be used to draw stylized outlines and strokes from 3D models, including occluding contours and Suggestive contours. For enhanced legibility, the most useful technical illustrations for technical communication are not necessarily photorealistic. Non-photorealistic renderings, such as exploded view diagrams, greatly assist in showing placement of parts in a complex system. Cartoon rendering, also called cel shading or toon shading, is a non-photorealistic rendering technique used to give 3D computer graphics a flat, cartoon-like appearance. Its defining feature is the use of distinct shading colors rather than smooth gradients, producing a look reminiscent of comic books or animated films. This technique is often used to blend 3D objects and environments with 2D hand-animated elements while maintaining a consistent look. Treasure Planet movie by Disney is an example of blending these techniques. == 2D == The input to a two dimensional NPR system is typically an image or video. The output is a typically an artistic rendering of that input imagery (for example in a watercolor, painterly or sketched style) although some 2D NPR serves non-artistic purposes e.g. data visualization. The artistic rendering of images and video (often referred to as image stylization) traditionally focused upon heuristic algorithms that seek to simulate the placement of brush strokes on a digital canvas. Arguably, the earliest example of 2D NPR is Paul Haeberli's 'Paint by Numbers' at SIGGRAPH 1990. This (and similar interactive techniques) provide the user with a canvas that they can "paint" on using the cursor — as the user paints, a stylized version of the image is revealed on the canvas. This is especially useful for people who want to simulate different sizes of brush strokes according to different areas of the image. Subsequently, basic image processing operations using gradient operators or statistical moments were used to automate this process and minimize user interaction in the late nineties (although artistic control remains with the user via setting parameters of the algorithms). This automation enabled practical application of 2D NPR to video, for the first time in the living paintings of the movie What Dreams May Come (1998). More sophisticated image abstractions techniques were developed in the early 2000s harnessing computer vision operators e.g. image salience, or segmentation operators to drive stroke placement. Around this time, machine learning began to influence image stylization algorithms notably image analogy that could learn to mimic the style of an existing artwork. The advent of deep learning has re-kindled activity in image stylization, notably with neural style transfer (NST) algorithms that can mimic a wide gamut of artistic styles from single visual examples. These algorithms underpin mobile apps capable of the same e.g. Prisma In addition to the above stylization methods, a related class of techniques in 2D NPR address the simulation of artistic media. These methods include simulating the diffusion of ink through different kinds of paper, and also of pigments through water for simulation of watercolor. == Artistic rendering == Artistic rendering is the application of visual art styles to rendering. For photorealistic rendering styles, the emphasis is on accurate reproduction of light-and-shadow and the surface properties of the depicted objects, composition, or other more generic qualities. When the emphasis is on unique interpretive rendering styles, visual information is interpreted by the artist and displayed accordingly using the chosen art medium and level of abstraction in abstract art. In computer graphics, interpretive rendering styles are known as non-photorealistic rendering styles, but may be used to simplify technical illustrations. Rendering styles that combine photorealism with non-photorealism are known as hyperrealistic rendering styles. == Notable films and games == This section lists some seminal uses of NPR techniques in films, games and software. See cel-shaded animation for a list of uses of toon-shading in games and movies.
Karen Spärck Jones
Karen Ida Boalth Spärck Jones (26 August 1935 – 4 April 2007) was a self-taught programmer and a pioneering British computer and information scientist responsible for the concept of inverse document frequency (IDF), a technology that underlies most modern search engines. She was an advocate for women in computer science, her slogan being, "Computing is too important to be left to men." In 2019, The New York Times published her belated obituary in its series Overlooked, calling her "a pioneer of computer science for work combining statistics and linguistics, and an advocate for women in the field." From 2008, to recognise her achievements in the fields of information retrieval (IR) and natural language processing (NLP), the Karen Spärck Jones Award is awarded annually to a recipient for outstanding research in one or both of her fields. == Early life and education == Karen Ida Boalth Spärck Jones was born in Huddersfield, Yorkshire, England. Her parents were Alfred Owen Jones, a chemistry lecturer, and Ida Spärck, a Norwegian who worked for the Norwegian government while in exile in London during World War II. Spärck Jones was educated at a grammar school in Huddersfield and then from 1953 to 1956 at Girton College, Cambridge, studying history, with an additional final year in Moral Sciences (philosophy). While at Cambridge, Spärck Jones joined the organisation known as the Cambridge Language Research Unit (CLRU) and met the head of CLRU Margaret Masterman, who would inspire her to go into computer science. While working at the CLRU, Spärck Jones began pursuing her PhD. At the time of submission, her PhD thesis was cast aside as uninspired and lacking original thought, but was later published in its entirety as a book. She briefly became a school teacher before moving into computer science. Spärck Jones married fellow Cambridge computer scientist Roger Needham in 1958. Spärck Jones's mother, Ida Spärck, had fled Norway on one of the last boats out after the German invasion in April 1940, going on to serve the Norwegian government in exile in London throughout the war. This background of displacement and resilience shaped the household in which Spärck Jones grew up. She later kept her mother's Norwegian surname professionally after marrying, stating that "it maintains a permanent existence of your own." Spärck Jones described her entry into computing as almost accidental. She had been working as a schoolteacher when she began visiting the CLRU out of curiosity about her husband's work. It was Margaret Masterman — whom she later described as "a very strange and interesting woman" — who offered her a research position and drew her fully into the field. == Career == Spärck Jones worked at the Cambridge Language Research Unit from the late 1950s, then at Cambridge University Computer Laboratory from 1974 until her retirement in 2002. From 1999, she held the post of Professor of Computers and Information. She had been given a permanent position only in 1993, and earlier in her career had been employed on a series of short-term contracts. She continued to work in the Computer Laboratory until shortly before her death. Her publications include nine books and numerous papers. A full list of her publications is available from the Cambridge Computer Laboratory. Spärck Jones' main research interests, since the late 1950s, were natural language processing and information retrieval. In 1964, Spärck Jones published "Synonymy and Semantic Classification", which is now seen as a foundational paper in the field of natural language processing. One of her most important contributions was the concept of inverse document frequency (IDF) weighting in information retrieval, which she introduced in a 1972 paper. IDF is used in most search engines today, usually as part of the term frequency–inverse document frequency (TF–IDF) weighting scheme. In the 1980s, Spärck Jones began her work on early speech recognition systems. In 1982 she became involved in the Alvey Programme which was an initiative to motivate more computer science research across the country. == Significance of inverse document frequency == At the time Spärck Jones was working, most computer scientists were focused on making people adapt to machines — learning precise codes and commands to retrieve information. Spärck Jones was working in the opposite direction: teaching computers to understand human language as it is actually used. Her 1972 paper introduced the concept of inverse document frequency (IDF) by observing that not all words carry equal informational value. A word like "the" appears in virtually every document and tells a retrieval system almost nothing about what any specific document is about. A rare word like "photosynthesis," by contrast, is highly specific and informative. IDF assigns each word a statistical weight based on how rarely it occurs across a document collection — the rarer the word, the higher its weight. When combined with term frequency (TF), which measures how often a word appears within a single document, the resulting TF–IDF score gives every word a relevance rating that can be used to rank documents in response to a search query. By 2007, Spärck Jones noted that "pretty much every web engine uses those principles." Her colleague John Tait remarked that "a lot of the stuff she was working on until five or ten years ago seemed like mad nonsense, and now we take it for granted." The 1972 paper remains among the most cited works in information retrieval research, with over 4,500 citations recorded in Google Scholar at the time of her death. The conceptual foundation of TF–IDF — that word meaning is statistical and contextual — has also informed later developments in machine learning and natural language processing, including transformer-based language models such as BERT. == Impact on artificial intelligence == Even though Spärck Jones' views on artificial intelligence (AI) were rather pessimistic in regard to the perceived limitations of AI in information retrieval, her work in natural language processing, information retrieval, and introducing the concept of inverse document frequency (IDF) contributed to the future technological development of AI. Her statistical and ranking methods shifted the direction of the development of AI towards being more expandable and led by data. Her work had a more indirect and conceptual impact on AI, compared to the current and direct impact it has had on search engines. == Gender and advocacy == Spärck Jones spent the majority of her career at Cambridge on short-term contracts without permanent employment, a situation she attributed directly to gender. In her 2001 IEEE oral history interview she stated that Cambridge was "in many ways not user-friendly, in the sense of women-friendly." She was frequently the only woman present in professional meetings throughout her career. She channelled this experience into active advocacy. She was a founding member of the women@cl network at Cambridge's Computer Laboratory, worked on outreach programmes aimed at encouraging girls into computing, and became widely known for her slogan: "Computing is too important to be left to men." She was the first woman ever to receive the BCS Lovelace Medal. === Honours and awards === These include: Gerard Salton Award (1988) Elected a Fellow of Association for the Advancement of Artificial Intelligence (AAAI) in 1993 President of the Association for Computational Linguistics (ACL) in 1994 Honorary degree of Doctor of Science from The City University in 1997. Elected a Fellow of the British Academy (FBA), where she also served as Vice-President in 2000–2002 Fellow of European Association for Artificial Intelligence (ECCAI) Association for Information Science and Technology (ASIS&T) Award of Merit (2002) Association for Computational Linguistics (ACL) Lifetime Achievement Award (2004) ACM - AAAI Allen Newell Award (2006) BCS Lovelace Medal (2007) Association for Computing Machinery (ACM) Women's Group Athena Award (2007) == Death and legacy == Spärck Jones died on 4 April 2007, due to cancer at the age of 71. In 2008, the BCS Information Retrieval Specialist Group (BCS IRSG) in conjunction with the British Computer Society established an annual Karen Spärck Jones Award in her honour, to encourage and promote research that advances understanding of Natural Language Processing or Information Retrieval. The Karen Spärck Jones lecture sponsored by BCS recognises the contribution that women have made to computing. In August 2017, the University of Huddersfield renamed one of its campus buildings in her honour. Formerly known as Canalside West, the Spärck Jones building houses the University's School of Computing and Engineering. When Spärck Jones died in 2007, The Times did not publish an obituary for her, despite having published one for her husband Roger Needham in 2003. In 2019, The New York Times included her in its Overlooked series under the title "Ove
Pushmeet Kohli
Pushmeet Kohli is an Indian British computer scientist and Vice President of research at Google DeepMind. At Deepmind, he heads the "Science and Strategic Initiatives Unit". He was noted by Time magazine as being one of the 100 most influential people in AI according to the Time 100 AI list. Kohli has led and supervised a number of projects including AlphaFold, a system for predicting the 3D structures of proteins; AlphaEvolve, a general-purpose evolutionary coding agent; SynthID, a system for watermarking and detecting AI-generated content; and Co-Scientist, an agent for generating and testing new scientific hypotheses. == Education == Kohli received a Bachelor of Technology (BTech) degree in Computer Science and Engineering at the National Institute of Technology, Warangal. He went on to study at Oxford Brookes University, where he earned a PhD in computer vision for research supervised by Philip Torr in 2007. == Career and research == After his PhD, Kohli was a postdoctoral associate at the Psychometric Centre, University of Cambridge. Before joining Google DeepMind, Kohli was partner scientist and director of research at Microsoft Research. His research investigates applications of machine learning and artificial intelligence. Kohli has made research contributions in the fields of computational biology, program synthesis, superoptimization, discrete optimization, and psychometrics. Notable research projects he has contributed to include: AlphaFold - breakthrough AI system for protein structure prediction AlphaEvolve - agent for code super optimization. AlphaTensor - Reinforcement learning agent for discovering new algorithms for matrix multiplication SynthID - system for watermarking AI generated images. AlphaGenome and AlphaMissense - AI models for predicting the effect of mutations in the genome AlphaCode - Competition-level code generation with AI FunSearch - Discovering algorithms using LLMs to search over program space. Neural Program Synthesis Probabilistic Programming Community based Crowdsourcing of Data for Training AI Models Behavioral analysis and personality prediction using online networks Human Pose Estimation using the Kinect Learnt Magnetic confinement control for Fusion Learnt Density Functional for solving the fractional electron problem === Awards and honours === Kohli's research in computer vision and machine learning has been recognized by a number of scientific awards and prizes. Some notable ones include: Koenderink Prize (Test of Time award) by the European Conference of Computer Vision British Machine Vision Association and Society for Pattern Recognition (BMVA) Sullivan Prize for the best PhD thesis. IEEE Mixed Augmented Reality (ISMAR) Impact Paper award Lasting Impact Award by the ACM Symposium on User Interface Software and Technology Best paper award at the International World Wide Web Conference 2014 Best paper award in the European Conference on Computer Vision (ECCV) 2010 Best paper award in the Conference on Uncertainty in Artificial Intelligence (UAI)
Models of DNA evolution
A number of different Markov models of DNA sequence evolution have been proposed. These substitution models differ in terms of the parameters used to describe the rates at which one nucleotide replaces another during evolution. These models are frequently used in molecular phylogenetic analyses. In particular, they are used during the calculation of likelihood of a tree (in Bayesian and maximum likelihood approaches to tree estimation) and they are used to estimate the evolutionary distance between sequences from the observed differences between the sequences. == Introduction == These models are phenomenological descriptions of the evolution of DNA as a string of four discrete states. These Markov models do not explicitly depict the mechanism of mutation nor the action of natural selection. Rather they describe the relative rates of different changes. For example, mutational biases and purifying selection favoring conservative changes are probably both responsible for the relatively high rate of transitions compared to transversions in evolving sequences. However, the Kimura (K80) model described below only attempts to capture the effect of both forces in a parameter that reflects the relative rate of transitions to transversions. Evolutionary analyses of sequences are conducted on a wide variety of time scales. Thus, it is convenient to express these models in terms of the instantaneous rates of change between different states (the Q matrices below). If we are given a starting (ancestral) state at one position, the model's Q matrix and a branch length expressing the expected number of changes to have occurred since the ancestor, then we can derive the probability of the descendant sequence having each of the four states. The mathematical details of this transformation from rate-matrix to probability matrix are described in the mathematics of substitution models section of the substitution model page. By expressing models in terms of the instantaneous rates of change we can avoid estimating a large numbers of parameters for each branch on a phylogenetic tree (or each comparison if the analysis involves many pairwise sequence comparisons). The models described on this page describe the evolution of a single site within a set of sequences. They are often used for analyzing the evolution of an entire locus by making the simplifying assumption that different sites evolve independently and are identically distributed. This assumption may be justifiable if the sites can be assumed to be evolving neutrally. If the primary effect of natural selection on the evolution of the sequences is to constrain some sites, then models of among-site rate-heterogeneity can be used. This approach allows one to estimate only one matrix of relative rates of substitution, and another set of parameters describing the variance in the total rate of substitution across sites. == DNA evolution as a continuous-time Markov chain == === Continuous-time Markov chains === Continuous-time Markov chains have the usual transition matrices which are, in addition, parameterized by time, t {\displaystyle t} . Specifically, if E 1 , E 2 , E 3 , E 4 {\displaystyle E_{1},E_{2},E_{3},E_{4}} are the states, then the transition matrix P ( t ) = ( P i j ( t ) ) {\displaystyle P(t)={\big (}P_{ij}(t){\big )}} where each individual entry, P i j ( t ) {\displaystyle P_{ij}(t)} refers to the probability that state E i {\displaystyle E_{i}} will change to state E j {\displaystyle E_{j}} in time t {\displaystyle t} . Example: We would like to model the substitution process in DNA sequences (i.e. Jukes–Cantor, Kimura, etc.) in a continuous-time fashion. The corresponding transition matrices will look like: P ( t ) = ( p A A ( t ) p A G ( t ) p A C ( t ) p A T ( t ) p G A ( t ) p G G ( t ) p G C ( t ) p G T ( t ) p C A ( t ) p C G ( t ) p C C ( t ) p C T ( t ) p T A ( t ) p T G ( t ) p T C ( t ) p T T ( t ) ) {\displaystyle P(t)={\begin{pmatrix}p_{\mathrm {AA} }(t)&p_{\mathrm {AG} }(t)&p_{\mathrm {AC} }(t)&p_{\mathrm {AT} }(t)\\p_{\mathrm {GA} }(t)&p_{\mathrm {GG} }(t)&p_{\mathrm {GC} }(t)&p_{\mathrm {GT} }(t)\\p_{\mathrm {CA} }(t)&p_{\mathrm {CG} }(t)&p_{\mathrm {CC} }(t)&p_{\mathrm {CT} }(t)\\p_{\mathrm {TA} }(t)&p_{\mathrm {TG} }(t)&p_{\mathrm {TC} }(t)&p_{\mathrm {TT} }(t)\end{pmatrix}}} where the top-left and bottom-right 2 × 2 blocks correspond to transition probabilities and the top-right and bottom-left 2 × 2 blocks corresponds to transversion probabilities. Assumption: If at some time t 0 {\displaystyle t_{0}} , the Markov chain is in state E i {\displaystyle E_{i}} , then the probability that at time t 0 + t {\displaystyle t_{0}+t} , it will be in state E j {\displaystyle E_{j}} depends only upon i {\displaystyle i} , j {\displaystyle j} and t {\displaystyle t} . This then allows us to write that probability as p i j ( t ) {\displaystyle p_{ij}(t)} . Theorem: Continuous-time transition matrices satisfy: P ( t + τ ) = P ( t ) P ( τ ) {\displaystyle P(t+\tau )=P(t)P(\tau )} Note: There is here a possible confusion between two meanings of the word transition. (i) In the context of Markov chains, transition is the general term for the change between two states. (ii) In the context of nucleotide changes in DNA sequences, transition is a specific term for the exchange between either the two purines (A ↔ G) or the two pyrimidines (C ↔ T) (for additional details, see the article about transitions in genetics). By contrast, an exchange between one purine and one pyrimidine is called a transversion. === Deriving the dynamics of substitution === Consider a DNA sequence of fixed length m evolving in time by base replacement. Assume that the processes followed by the m sites are Markovian independent, identically distributed and that the process is constant over time. For a particular site, let E = { A , G , C , T } {\displaystyle {\mathcal {E}}=\{A,\,G,\,C,\,T\}} be the set of possible states for the site, and p ( t ) = ( p A ( t ) , p G ( t ) , p C ( t ) , p T ( t ) ) {\displaystyle \mathbf {p} (t)=(p_{A}(t),\,p_{G}(t),\,p_{C}(t),\,p_{T}(t))} their respective probabilities at time t {\displaystyle t} . For two distinct x , y ∈ E {\displaystyle x,y\in {\mathcal {E}}} , let μ x y {\displaystyle \mu _{xy}\ } be the transition rate from state x {\displaystyle x} to state y {\displaystyle y} . Similarly, for any x {\displaystyle x} , let the total rate of change from x {\displaystyle x} be μ x = ∑ y ≠ x μ x y . {\displaystyle \mu _{x}=\sum _{y\neq x}\mu _{xy}\,.} The changes in the probability distribution p A ( t ) {\displaystyle p_{A}(t)} for small increments of time Δ t {\displaystyle \Delta t} are given by p A ( t + Δ t ) = p A ( t ) − p A ( t ) μ A Δ t + ∑ x ≠ A p x ( t ) μ x A Δ t . {\displaystyle p_{A}(t+\Delta t)=p_{A}(t)-p_{A}(t)\mu _{A}\Delta t+\sum _{x\neq A}p_{x}(t)\mu _{xA}\Delta t\,.} In other words, (in frequentist language), the frequency of A {\displaystyle A} 's at time t + Δ t {\displaystyle t+\Delta t} is equal to the frequency at time t {\displaystyle t} minus the frequency of the lost A {\displaystyle A} 's plus the frequency of the newly created A {\displaystyle A} 's. Similarly for the probabilities p G ( t ) {\displaystyle p_{G}(t)} , p C ( t ) {\displaystyle p_{C}(t)} and p T ( t ) {\displaystyle p_{T}(t)} . These equations can be written compactly as p ( t + Δ t ) = p ( t ) + p ( t ) Q Δ t , {\displaystyle \mathbf {p} (t+\Delta t)=\mathbf {p} (t)+\mathbf {p} (t)Q\Delta t\,,} where Q = ( − μ A μ A G μ A C μ A T μ G A − μ G μ G C μ G T μ C A μ C G − μ C μ C T μ T A μ T G μ T C − μ T ) {\displaystyle Q={\begin{pmatrix}-\mu _{A}&\mu _{AG}&\mu _{AC}&\mu _{AT}\\\mu _{GA}&-\mu _{G}&\mu _{GC}&\mu _{GT}\\\mu _{CA}&\mu _{CG}&-\mu _{C}&\mu _{CT}\\\mu _{TA}&\mu _{TG}&\mu _{TC}&-\mu _{T}\end{pmatrix}}} is known as the rate matrix. Note that, by definition, the sum of the entries in each row of Q {\displaystyle Q} is equal to zero. It follows that p ′ ( t ) = p ( t ) Q . {\displaystyle \mathbf {p} '(t)=\mathbf {p} (t)Q\,.} For a stationary process, where Q {\displaystyle Q} does not depend on time t, this differential equation can be solved. First, P ( t ) = exp ( t Q ) , {\displaystyle P(t)=\exp(tQ),} where exp ( t Q ) {\displaystyle \exp(tQ)} denotes the exponential of the matrix t Q {\displaystyle tQ} . As a result, p ( t ) = p ( 0 ) P ( t ) = p ( 0 ) exp ( t Q ) . {\displaystyle \mathbf {p} (t)=\mathbf {p} (0)P(t)=\mathbf {p} (0)\exp(tQ)\,.} === Ergodicity === If the Markov chain is irreducible, i.e. if it is always possible to go from a state x {\displaystyle x} to a state y {\displaystyle y} (possibly in several steps), then it is also ergodic. As a result, it has a unique stationary distribution π = { π x , x ∈ E } {\displaystyle {\boldsymbol {\pi }}=\{\pi _{x},\,x\in {\mathcal {E}}\}} , where π x {\displaystyle \pi _{x}} corresponds to the proportion of time spent in state x {\displaystyle x} after the Markov chain has run for an infinite amount of time. In DNA evo
Pill reminder
A pill reminder is any device that reminds users to take medications. Traditional pill reminders are pill containers with electric timers attached, which can be preset for certain times of the day to set off an alarm. More sophisticated pill reminders can also detect when they have been opened, and therefore when the user is away during the time they were supposed to take their medication, they will be reminded of it when they return. This reminder can be in the form of a light, which also helps for deaf or hearing-impaired users. == Mobile app == A newer type of pill reminder is a mobile app that reminds the owner to take the medication. Some of these applications might effectively support adherence to taking medications.
How to Choose an AI Sales Assistant
In search of the best AI sales assistant? An AI sales assistant is software that uses machine learning to help you get more done — it turns a rough idea into a polished result in seconds. When choosing one, weigh output quality, pricing, export formats, and how well it fits the tools you already use. Whether you are a beginner or a pro, the right AI sales assistant slots into your workflow and pays for itself fast. Below we compare features, pricing, and real output so you can choose with confidence.